Susan Mastrangelo was born in New York City to parents who had studied at the Art Students League. Her mother continued to paint, while her father gravited to newspapers, and became a journalist. When Ms. Mastrangelo  turned fourteen, her family moved to Washingont DC in order for her father to pursue a job on the Washinton Post as a journalist. She studied at the Kansas City Art Institute and the New York Studio School, and received her MFA from Boston University while studying with Philip Guston. 
She has had one person shows in New York City, New Hampshire, Connecticut, Hudson New York, Brooklyn, and has participated in numerous group shows. Ms. Mastrangelo is a recipient of a Rockwell Grant, two grants from the Pollack Krasner Foundation, a visiting artist at the American Acedemy in Rome, a guest at Civitella Raneri, and awarded residencies at Yaddo, The Virginia Center for the Arts, The Ragdale Foundation, The Triangle Workshop, and the Tyrone Guthrie Center. Ms. Mastrangelo taught and chaired the Art Department at The Buckley School in Manhattan for twenty six years, and now works as a full time artist with a studio in the Can Factory, located in Gowanus, Brooklyn, New York.